G-AlphaS Signaling

Description:

G-proteins are heterotrimers, consisting of Alpha, Beta and Gamma subunits, and are involved in signaling to distinct effectors. Heterotrimeric G-proteins convey extracellular signals that activate 7-transmembrane-spanning GPCRs (G-Protein-Coupled Receptors) to the inside of cells, communicating this information to effector proteins and thus initiating changes in cell behaviour. GPCRs constitute a large and diverse family of proteins whose primary function is to transduce extracellular stimuli into intracellular signals. GPCR...

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.
O'Hayre M, Degese MS, Gutkind JS.
Curr Opin Cell Biol. 2014 Apr;27:126-35. doi: 10.1016/j.ceb.2014.01.005. Epub 2014 Feb 6. Review.
Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.
Masuho I, Ostrovskaya O, Kramer GM, Jones CD, Xie K, Martemyanov KA.
Sci Signal. 2015 Dec 1;8(405):ra123. doi: 10.1126/scisignal.aab4068.
G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.
Tilley DG.
Circ Res. 2011 Jul 8;109(2):217-30. doi: 10.1161/CIRCRESAHA.110.231225. Review.
PKA controls calcium influx into motor neurons during a rhythmic behavior.
Wang H, Sieburth D.
PLoS Genet. 2013;9(9):e1003831. doi: 10.1371/journal.pgen.1003831. Epub 2013 Sep 26.

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Pathways

G-AlphaS Signaling

Description:

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.

PKA controls calcium influx into motor neurons during a rhythmic behavior.

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Institutional License

Pathways

G-AlphaS Signaling

Description:

References:

Novel insights into G protein and G protein-coupled receptor signaling in cancer.

Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors.

G protein-dependent and G protein-independent signaling pathways and their impact on cardiac function.

PKA controls calcium influx into motor neurons during a rhythmic behavior.

Databases

Tools

Institutional License

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